Dr Ruchi Shukla

Assistant Professor

School: Geography and Natural Sciences

Email Ruchi

Key Publications

Endogenous retroelement activation is implicated in IFN-α production and anti-CCP autoantibody generation in early Rheumatoid Arthritis, Cooles, F., Pedrola, G., Naamane, N., Pratt, A., Barron‐Millar, B., Anderson, A., Hilkens, C., Casement, J., Bondet, V., Duffy, D., Zhang, F., Shukla, R., Isaacs, J. 1 Jun 2025, In: Arthritis and Rheumatism
Identification of TIAM1 as a Potential Synthetic-Lethal-like Gene in a Defined Subset of Hepatocellular Carcinoma, Permtermsin, C., Lalchungnunga, H., Nakjang, S., Casement, J., Ogle, L., Reeves, H., Strathdee, G., Shukla, R., Welsh, M. 28 Mar 2023, In: International Journal of Molecular Sciences
Impact of retrotransposon protein L1 ORF1p expression on oncogenic pathways in hepatocellular carcinoma: the role of cytoplasmic PIN1 upregulation, Zadran, B., Sudhindar, P., Wainwright, D., Bury, Y., Luli, S., Howarth, R., McCain, M., Watson, R., Huet, H., Palinkas, F., Palmini, R., Casement, J., Mann, D., Oakley, F., Lunec, J., Reeves, H., Faulkner, G., Shukla, R. 30 Mar 2023, In: British Journal of Cancer
Regulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway, Hunter, J., Campbell, A., Hannaway, N., Kerridge, S., Luli, S., Butterworth, J., Sellier, H., Mukherjee, R., Dhillon, N., Sudhindar, P., Shukla, R., Brownridge, P., Bell, H., Coxhead, J., Taylor, L., Leary, P., Hasoon, M., Collins, I., Garrett, M., Eyers, C., Perkins, N. 14 Oct 2022, In: Biochemical Journal
Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma?, Zaki, M., Alhasan, S., Shukla, R., McCain, M., Laszczewska, M., Geh, D., Patman, G., Televantou, D., Whitehead, A., Maurício, J., Barksby, B., Gee, L., Paish, H., Leslie, J., Younes, R., Burt, A., Borthwick, L., Thomas, H., Beale, G., Govaere, O., Sia, D., Anstee, Q., Tiniakos, D., Oakley, F., Reeves, H. 13 Dec 2022, In: Liver Cancer
A PDCD1 Role in the Genetic Predisposition to NAFLD-HCC?, Eldafashi, N., Darlay, R., Shukla, R., McCain, M., Watson, R., Liu, Y., McStraw, N., Fathy, M., Fawzy, M., Zaki, M., Daly, A., Maurício, J., Burt, A., Haugk, B., Cordell, H., Bianco, C., Dufour, J., Valenti, L., Anstee, Q., Reeves, H. 19 Mar 2021, In: Cancers
HCV activates somatic L1 retrotransposition—a potential hepatocarcinogenesis pathway, Sudhindar, P., Wainwright, D., Saha, S., Howarth, R., McCain, M., Bury, Y., Saha, S., McPherson, S., Reeves, H., Patel, A., Faulkner, G., Lunec, J., Shukla, R. 11 Oct 2021, In: Cancers
Key features of the environment promoting liver cancer in the absence of cirrhosis, Zaki, M., Mahdi, A., Patman, G., Whitehead, A., Maurício, J., McCain, M., Televantou, D., Abou-Beih, S., Ramon-Gil, E., Watson, R., Cox, C., Leslie, J., Wilson, C., Govaere, O., Lunec, J., Mann, D., Nakjang, S., Oakley, F., Shukla, R., Anstee, Q., Tiniakos, D., Reeves, H. 1 Dec 2021, In: Scientific Reports
Activation of transcription factor circuity in 2i-induced ground state pluripotency is independent of repressive global epigenetic landscapes, Shukla, R., Mjoseng, H., Thomson, J., Kling, S., Sproul, D., Dunican, D., Ramsahoye, B., Wongtawan, T., Treindl, F., Templin, M., Adams, I., Pennings, S., Meehan, R. 20 Aug 2020, In: Nucleic Acids Research
DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency, McLaughlin, K., Flyamer, I., Thomson, J., Mjoseng, H., Shukla, R., Williamson, I., Grimes, G., Illingworth, R., Adams, I., Pennings, S., Meehan, R., Bickmore, W. 12 Nov 2019, In: Cell Reports

PGR Supervision

Nefeli Tzanaki Population genetic analysis based on the polymorphisms mediated by retrotransposons in the human genomes for cancer risk prediction Start Date: 01/10/2025 End Date: 17/10/2025
Ayodeji Olushola Awotula Understanding the interactions between L1 ORF1 protein and other cellular proteins in the context of oncogenic pathways Start Date: 01/11/2024 End Date: 17/10/2025
Ayodeji Olushola Awotula Understanding the interactions between L1 ORF1 protein and other cellular proteins in the context of oncogenic pathways Start Date: 01/11/2024
Nefeli Tzanaki Exploring genetic variants for liver cancer risk prediction: a focus on retrotransposon polymorphisms Start Date: 01/10/2025